Browsing by Author "Subhashini K. Sripathi"
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- ItemAllantoin from the leaves of Pisonia grandis R.Br.(2011) Subhashini K. Sripathi; Lalitha, PPhytochemical investigation o f the leaves o f the Pisonia grandis afforded three compounds (I-3). Compound I was identified as the insulin mimetic molecule pinitol and its isolation was reported in our earlier paper'. The present paper deals with the isolation o f compounds 2 and 3. whose structures were established as that o f allantoin and its hydrogen bonded isomeric crystalline form, based on spectroscopic data and it is the first report o f isolation of allantoin and its hydrogen bonded isomer from Pisonia genus and from this species.
- ItemAnti diabetic agent Pinitol from the leaves of Pisonia grandis (R.Br.)(2010) Subhashini K. SripathiPhytochemical investigation of the leaves of Pisonia grandis afforded an anti- diabetic compound. Its structure was established as pinitol based on spectroscopic data. It is the first report of isolation o f pinitol from Pisonia genus and from this species also.
- ItemAnti-Diabetic Activity Of Aqueous Extract Of Pithecellobium Duke Benth Fruit Peel On Streptozotocin Induced Diabetic Rats(2016) Subhashini K. SripathiThe decoction of the Pithecellobium dulce faiit peel has been used for the control of diabetes mellitus in the traditional method adopted by the local people of northwest region of Tamil Nadu, India. The present study was carried out to investigate the anti-diabetic potential of aqueous extract of Pithecellobium dulce fruit peel by its oral administration (200 mg/kg) to streptozotocin-induced diabetic rats. The levels of blood glucose, urine sugar, glycosylated hemoglobin, glucose-6-phosphatase, fructose-1,6-bisphosphatase, total cholesterol, triglycerides, aspartate transaminase, alanine transaminase, alkaline phosphatase and reduced glutathione were increased significantly whereas the levels of plasma insulin, hexokinase, protein, liver glycogen, reduced glutathione, superoxide dismutase, catalase and glutathione peroxidase were decreased in streptozotocin-induced diabetic rats and it was normalized after treatment of aqueous extract. Glibenclamide was used as the standard drug. These outcomes suggest that the aqueous extract possesses antidiabetic activity and supports the traditional use of the Pithecellobium dulce fruit peel decoction as hypoglycemic agent.
- ItemAntibacterial Activity of Selected Medicinal Plant in Traditional Treatment of Wound Infection in Southeast India(2014) Subhashini K. SripathiObjective: The wound healing potential of fruit peel of Pithecellobium dulce Benth, a plant traditionally used for wound treatment against woundinfecting bacteria, was assessed using disc diffusion and microtitre plate methods. Methods: P. duke fruit peel was extracted using ethyl acetate, methanol and water and tested for their antimicrobial activities against bacterial isolates from wound infection using disc diffusion and microtitre plate methods. Results: All the three extracts had antimicrobial activities, among which methanol extract had higher activities against all the tested organisms compared to the ethyl acetate and aqueous extracts. The most susceptible organism to all the extracts was K pneumonia and S. aureus while the most resistant were P. mirabilis and P. vulgaris. Conclusion: The potential antibacterial activity of P. dulce plant against both gram-positive and gram-negative bacteria justifies the use of the plant as the wound healing agent. The isolation of active principle of this plant may serve as source and lead for the synthesis of drugs in pharmaceutical industries.
- ItemAntibactirial Activity of Selected Medicinal Plant in Treditional Treatment of Wound Infection in Southeast India(2014) Subhashini K. SripathiObjective: The wound healing potential of fruit peel of Pithecellobium dulce Benth, a plant traditionally used for wound treatment against woundinfecting bacteria, was assessed using disc diffusion and microdtre plate methods. Methods: P. duke fruit peel was extracted using ethyl acetate, methanol and water and tested for their antimicrobial activities against bacterial isolates from wound infection using disc diffusion and microtitre plate methods. Results: All the three extracts had antimicrobial activities, among which methanol extract had higher activities against ail the tested organisms compared to the ethyl acetate and aqueous extracts. The most susceptible organism to all the extracts was K pneumonia and S. aureus while the most resistant were P. mirabilis and P. vulgaris. Conclusion: The potential antibacterial activity of P. dulce plant against both gram-positive and gram-negative bacteria justifies the use of the plant as the wound healing agent The isolation of active principle of this plant may serve as source and lead for the synthesis of drugs in pharmaceutical industries.
- ItemAntifungal Activity of Beterocycles Sinthesized Under Microwave Radiation(2010) Subhashini K. SripathiQuinoline compounds posses? a wide rarvae. :i antibscierial, ar.tifungai and antimoxagenic properties. Tr.e present work Involves synthesis of three heterocycies-4- p’henyi 5-vinyi quinotin-2-on8 (1), 4-phenyl-3-ch!oroqijinoline (2), 4-phenyl-3-vinyl quinoline-2-thlone (3) utilizing microwave technology and testing their antifungal activity against 4 fungi namely Aspergillus flavus, Rhizopus nigricans, Mucor hiemaiis and Candida albicans. Antifungal studies of compounds showed good fungal activity. The antimicrobial significance of the synthesized compounds is we!! evident from the study.
- ItemAntioxidant and Antibacterial Activities of Train Thema Decandra Linn(2012) Subhashini K. SripathiTrianthema decandra (Vellai sharuni in Tamil and Gadabani in Hindi) is a prostrate weed widely distributed in India. Its root is traditionally used in the treatment of hepatitis and asthma and for wound-healing. The antioxidant and antibacterial potential of Trianthema decandra was assessed and the results revealed significant activity in the ethyl acetate and methanolic extracts of roots and leaves of the plant
- ItemAntioxidant and Antibactirial Activities of Triyanthema Decantra Linn(2012) Subhashini K. SripathiTrianthema decandra (Veltai sharuni in Tamil and Gadabani in Hindi) is a prostrate weed widely distributed in India. Its root is traditionally used in the treatment of hepatitis and asthma and for wound-healing The antioxidant and antibacterial potential of Trianthema decandra was assessed and the results revealed significant activity in the ethyl acetate and methanolic extracts of roots and leaves of the plant
- ItemBioassay Guided Fractionation and Antifungal Activity Studies on Pisonia grandis R .B R .(2010) Subhashini K. SripathiPisonia grandis is an herb claimed to be used for treatment of various diseases by local folks. Since, this plant possesses many medicinal properties; there are not many scientific studies carried out on this plant which promoted us to pursue a systematic pharmacological evaluation of Pisonia grandis leaves to verify their medicinal properties. Bioassay- guided fractionation of ethanol extract of leaves of Pisonia grandis was studied for its anti-fungal activity against microorganisms Candida albicans, Aspergillus niger, Pencillium citrinum and Monascuspiirpureiis by disc diffusion method. The ethanol extract showed good anti-flingal activity against Monascus purpureas comparable to standard clotrimazole.
- ItemBioassay Fractionation Based Antifungal Assay of Stems of Cissus Quadrangularis(2015) Subhashini K. Sripathi
- ItemBioassay Fractionation Based Antifungal Assay of Stems of Cissus Quadrangularis (Linn.)(2015) Subhashini K. SripathiCissus quadrangularis is a herb claimed to be used for the treatment of various diseases by common man. This plant possesses immense medicinal potential and since there are not many scientific studies carried out on the stem parts of this plan, the biological evaluation of the stems was taken up. The ethanol extract of stems of cissus quadrangularis was analyzed for its antifungal activity by disc diffusion method. The ethanol extract showed antifungal activity against Monoscus ruber comparable to that of standard clotrimazole..
- ItemChemical composition and antibacterial activity of the essential oil from the aerial parts of Aristolochia tagala(2010) Subhashini K. SripathiThe chemical composition of the essential oil obtained by hydrodistillation of the aerial parts of Aristolochia tagala was analysed using Gas Cromatography-Mass Spectrometry method. Thirty seven compounds in the oil were identified. The major components were the sesquiterpenes, namely, P-caryophyllene (13.8%), a-humulene (6.5%), germacrene-A (4.3%), bicyclogermacrene (4.2%) and caiyophyllene oxide (3.9%). The oil showed moderate antibacterial activity against the tested Gram-positive and Gram-negative bacteria.
- ItemChemical Composition and Antibacterial Activity of the Essential Oil from the Aerial Parts of Aristolochia Tagala(2010) Subhashini K. SripathiThe chemical composition of the essentia! oil obtained by hydrodistillation of the aerial parts of Aristolochia tagala was analysed using Gas Cromatography-Mass Spectrometry method. Thirty seven compounds in the oil were identified. The major components were the sesquiterpenes, namely, P-caryophyllene (13.8%), a-humulene (6.5%), gemiacrene-A (4.3%), bicyclogermacrene (4.2%) and car>'ophyllene oxide (3.9%). The oil showed moderate antibacterial activity against the tested Gram-positive and Gram-negative bacteria.
- ItemCorynebacterium Inhibiting P.grandis Based Herbal Textile(2015) Subhashini K. Sripathi; Lalitha, PAntimicrobial finishes have increased its importance in the recent years for several reasons necessitating this research work. Herbal extracts are promising in antimicrobial activity without much side effects. Hence the aim of this work was focused on fabricating antimicrobial textile finishes with antibacterial activity against Corynebacterium a common sweat - bacterium posing bad odour and skin problems. Solvent extracts of P.grandis coated onto to cotton cloth samples by sonication method were tested for anti- corynebacterium activity by disc diffusion method according to AATCC 147 method. Good antibacterial activity was noted since there was no growth under and above the fabric samples. The leaching of extracts was also not noted as there was no zone of inhibition around tlie test samples. Tliese results tlirow open the scope of developing newer antimicrobial herbal textile finishes.
- ItemCyclic Voltammetric Behaviour of The Ethanol Extracts of Pisonia Grandis(R.Br)(2011) Subhashini K. SripathiAntioxidants help organisms deal with oxidative stress, caused by free radical damage. In the present study, ethanol extract of Pisonia grandis and its 90% ethanol fractionate were subjected to electrochemical analysis by cyclic voltammetry using KCl as supporting electrolyte at glassy carbon electrode at various concentrations and scan rates. Both the extracts had a reversible and an irreversible redox reaction. The electrochemical response is directly related to the structure of the antioxidant and the potential required for its oxidation.
- ItemCyclic Voltammetric Behaviour of The Ethanol Extracts of Pisonia Grandis(R.Br)(2011) Subhashini K. SripathiAntioxidants help organisms deal with oxidative stress, caused by free radical damage. In the present study, ethanol extract of Pisonia grandis and its 90% ethanol fractionate were subjected to electrochemical analysis by cyclic voltammetry using KCI as supporting electrolyte at glassy carbon electrode at various concentrations and scan rates. Both the extracts had a reversible and an irreversible redox reaction. The electrochemical response is directly related to the structure of the antioxidant and the potential required for its oxidation.
- ItemDocumentation of Physiochemical Parameters of the Folkloric Medicinal Plant Pisonia Grandis R.Br. Reared under Greenhouse and Local Environment Conditions(2015) Subhashini K. SripathiMedicinal plants represent the eternal kindness of almighty for the perpetuation of hfe in the universe. Pisonia grandis R.Br. is a flowering plant of the four O’clock family Nyctaginaceae, commonly called lettuce tree. The medicinal potential of the plant is well established and is documented by many workers. The present study is aimed to document the physiochemical parameters of the plant P. grandis reared under green house and local environment conditions. Standard methods were adopted for the physiochemical analyses. Physiochemical parameters of leaves, stem and roots of P. grandis revealed that the plant parts are a rich source of metabohtes, micro and macro nutrients, minerals, fibers and proteins. Toxic metal contamination in leaves stems and roots of P. grandis are within the World Health Organization (WHO) permissible hmits. All feasible documentation obtained from the current investigation makes it a wholesome record on physiochemical parameters of the folkloric medicinal plant P. grandis.
- ItemElectrochemical Behavior of the Aqueous Fraction of the Ethanol Extract of Pisonia Grandis (RBr) at Glassy Carhon Electrode(2011) Subhashini K. SripathiPisonia grandis (R.Br) (grand .devil’s claw) Qfyctaginaceae) is a lettuce tree having anti-inflanunatory, antidiabedc, diuretic, and wound healing activity. Antioxidant activity of aqueous fraction o f ethanol extract o f Pisonia grandis (R.Br) was analyzed by its electrochemical behavior. Cyclic voltammetry o f the aqueous fraction of the ethanol extract at glassy carbon electrode with KCl as supporting electrolyte revealed a reversible and an irreversible redox reaction whidi is due to the presence of one or more secondary metabolites like flavonoids, phenols and tri-terpenoids having antioxidant prq)erties
- ItemElectrochemical Behavior of the Aqueous Fraction of the Ethanol Extract oiPisonia grandis (R.Br) at Glassy Carhon Electrode(2011) Subhashini K. SripathiPisonia grandis (R-Br) (grand |devil’s claw) Qfyctaginaceae) is a lettuce tree having anti-inflanunatoiy, antidiabetic, diuretic, and wound healing activity. Antioxidant activity of aqueous fraction of ethanol extract o f Pisonia grandis (R.Br) was analyzed by its electrochemical bdiavior. Cyclic voltammetry o f the aqueous fraction o f the ethanol extract at glassy carbon elec tive with KCl as su j^ rtin g electrolyte revealed a reversible and an irreversible redox reaction which is due to the presence of one or more secondary metabolites like flavonoids, phenols and tri-terpenoids having antioxidant propoties
- ItemEthno Medicinal Practices of Tribal Inhabitants Attappady and Vakkodan Hill Regions of Kerala(2013) Subhashini K. Sripathi
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