Anti-Diabetic Activity Of Aqueous Extract Of Pithecellobium Duke Benth Fruit Peel On Streptozotocin Induced Diabetic Rats
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Date
2016
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Abstract
The decoction of the Pithecellobium dulce faiit peel has been used for the control of diabetes mellitus in the traditional
method adopted by the local people of northwest region of Tamil Nadu, India. The present study was carried out to
investigate the anti-diabetic potential of aqueous extract of Pithecellobium dulce fruit peel by its oral administration (200
mg/kg) to streptozotocin-induced diabetic rats. The levels of blood glucose, urine sugar, glycosylated hemoglobin,
glucose-6-phosphatase, fructose-1,6-bisphosphatase, total cholesterol, triglycerides, aspartate transaminase, alanine
transaminase, alkaline phosphatase and reduced glutathione were increased significantly whereas the levels of plasma
insulin, hexokinase, protein, liver glycogen, reduced glutathione, superoxide dismutase, catalase and glutathione
peroxidase were decreased in streptozotocin-induced diabetic rats and it was normalized after treatment of aqueous
extract. Glibenclamide was used as the standard drug. These outcomes suggest that the aqueous extract possesses antidiabetic
activity and supports the traditional use of the Pithecellobium dulce fruit peel decoction as hypoglycemic agent.