Anti-Diabetic Activity Of Aqueous Extract Of Pithecellobium Duke Benth Fruit Peel On Streptozotocin Induced Diabetic Rats

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dc.categoryJournal Article
dc.contributor.authorSubhashini K. Sripathi
dc.date.accessioned2017-11-15T09:39:05Z
dc.date.available2017-11-15T09:39:05Z
dc.date.issued2016
dc.departmentChemistryen_US
dc.description.abstractThe decoction of the Pithecellobium dulce faiit peel has been used for the control of diabetes mellitus in the traditional method adopted by the local people of northwest region of Tamil Nadu, India. The present study was carried out to investigate the anti-diabetic potential of aqueous extract of Pithecellobium dulce fruit peel by its oral administration (200 mg/kg) to streptozotocin-induced diabetic rats. The levels of blood glucose, urine sugar, glycosylated hemoglobin, glucose-6-phosphatase, fructose-1,6-bisphosphatase, total cholesterol, triglycerides, aspartate transaminase, alanine transaminase, alkaline phosphatase and reduced glutathione were increased significantly whereas the levels of plasma insulin, hexokinase, protein, liver glycogen, reduced glutathione, superoxide dismutase, catalase and glutathione peroxidase were decreased in streptozotocin-induced diabetic rats and it was normalized after treatment of aqueous extract. Glibenclamide was used as the standard drug. These outcomes suggest that the aqueous extract possesses antidiabetic activity and supports the traditional use of the Pithecellobium dulce fruit peel decoction as hypoglycemic agent.en_US
dc.identifier.issn2321-807X
dc.identifier.urihttps://ir.avinuty.ac.in/handle/avu/3650
dc.langEnglishen_US
dc.publication.categoryJournal Articleen_US
dc.publisher.nameJournal of Advanced Chemistryen_US
dc.publisher.typeInternationalen_US
dc.titleAnti-Diabetic Activity Of Aqueous Extract Of Pithecellobium Duke Benth Fruit Peel On Streptozotocin Induced Diabetic Ratsen_US
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