Cytotoxic properties of Acorns calamus in MCF -7 breast cancer cells
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Date
2013
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Abstract
In this study cytotoxic effect of Acorus calamus extract was evaluated on
breast carcinoma (MCF-7) cell lines. MCF-7 cells were cultured in DMEM
medium and incubated with different concentrations (18.75, 37.5, 75, 150 and
300 |tg/ml) of Acorus calamus methanol extract. Cell viability was assessed
by MTT assay. Acorus calamus decreased cell viability in malignant cells in a
concentration dependent maimer. The IC50 values in MCF-7 cells were
determined as 52.07 pg/ml. It may be concluded that Acorus calamus can
cause cell death in MCF-7 cancer cells which can be considered as a
promising chemotherapeutic agent in breast cancer treatment.