Neuroprotective effect of synthesized zinc oxide nanoparticle - capped catechin
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Date
2024-06
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Avinashilingam
Abstract
Nanotechnology is a prolonged branch of existing research that involves the
fabrication and customization of particle structures with typical sizes of less than 100 nm.
A large area of surface-to-volume ratio was related to minimum surface functionalization,
resulting in nanostructured metal oxide nanoparticles with outstanding biological activity.
The biosynthesis of nanoparticles has become an important research area because of their
remarkable environmental friendliness and biocompatibility. Catechin, a group of
polyphenolic compounds is widely used as nutraceuticls, Zinc oxide in the form of
nanoparticles, can enhance beneficial therapeutic effects to the development of
nanotechnology shown to have neurogenic and neuroprotective effects, regeneration and
repair of damaged brain tissue, cortical neurons synaptic connection and synaptic
plasticity and ultimately promote regeneration. Camellia sinensis is one of the most
popular plants used in green tea production worldwide, which possesses the antioxidant
and neuroprotective properties. The aim of this research is the synthesized zinc oxide
nanoparticle-capped catechin and investigation of their neuroprotective potential. Zinc
oxide nanoparticles synthesized form the Camellia sinensis leaf extract by nano
precipitation method, then capped with catechin. The nanoparticles were characterized by
different techniques, such as UV Vis spectrophotometer, Scanning electron microscopy,
Zeta potential, Fourier transform infrared spectroscopy and X-ray diffraction analysis.
Synthesized zinc oxide nanoparticle-capped catechin exhibited the antioxidant activity was
determined using the DPPH radical scavenging activity. Synthesized zinc oxide
nanoparticle-capped catechin has significantly inhibited the acetylcholinesterase activity.
A dose-dependent cell viability of synthesized zinc oxide nanoparticle-capped catechin
has been observed against Neuro 2a cells. .
Key words: Zinc oxide nanoparticles, catechin, Camellia sinensis, neuro 2a cells,
neuroprotective, antioxidant, acetylcholinesterase
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Biochemistry