Anticancer Activity of Methanol Extract of Green Tea against Cervical Cancer

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dc.categoryConference Proceedings
dc.contributor.authorSanthy, K S
dc.contributor.authorGeetha, B
dc.date.accessioned2017-01-24T18:24:00Z
dc.date.available2017-01-24T18:24:00Z
dc.date.issued2016
dc.departmentLife Science - Zoologyen_US
dc.description.abstractIdentification and development of natural products used for cancer prevention have attracted a lot of attention globally. Herbal extracts with their proven potential and less side effects in therapeutics have replaced the synthetically derived drugs in modern allopathic medication system. In a low resource country like India, an inexpensive dietary chemopreventive intervention would be an attractive adjunct to existing cervical cancer prevention programs. It is observed that the studies on the relationship between cervical cancer and green I tea are limited, and the observational data are very rare. Hence, in this study an attempt was made to find out the efficacy of methanol extract of green tea against cervical cancer cells (HeLa) by in vitro model systems; and to study the DNA repair capacity of green tea extracts on cultured lymphocytes of cervical cancer patients. It was found that the green tea decreased k cell viability in malignant cells in a concentration dependent manner and the IC50 value of green tea extract was found to be 111.9 ygfml. Chromosomal aberration studies indicate that methanolic extract of green tea showed a reduction in the number of Chromatid Type Aberration i (CTA) in the experimental samples when compared to control samples. Hence, it may be concluded that since green tea could cause cell death in HeLa cells and reduce the DNA damage in cultured lymphocytes of cervical cancer patients it can be considered as a potent anticancer agent against cervical carcinogenesis.en_US
dc.identifier.urihttps://ir.avinuty.ac.in/handle/avu/1117
dc.langEnglishen_US
dc.publisher.nameDaya Publishing House' A Division o f Astral International Pvt. Ltd. New Delhi - 110 002en_US
dc.publisher.typeInternationalen_US
dc.titleAnticancer Activity of Methanol Extract of Green Tea against Cervical Canceren_US
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