Anticancer Activity of Methanol Extract of Green Tea against Cervical Cancer
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Date
2016
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Abstract
Identification and development of natural products used for cancer prevention have
attracted a lot of attention globally. Herbal extracts with their proven potential and less side
effects in therapeutics have replaced the synthetically derived drugs in modern allopathic
medication system. In a low resource country like India, an inexpensive dietary chemopreventive
intervention would be an attractive adjunct to existing cervical cancer prevention
programs. It is observed that the studies on the relationship between cervical cancer and green
I tea are limited, and the observational data are very rare. Hence, in this study an attempt was
made to find out the efficacy of methanol extract of green tea against cervical cancer cells
(HeLa) by in vitro model systems; and to study the DNA repair capacity of green tea extracts
on cultured lymphocytes of cervical cancer patients. It was found that the green tea decreased
k cell viability in malignant cells in a concentration dependent manner and the IC50 value of
green tea extract was found to be 111.9 ygfml. Chromosomal aberration studies indicate that
methanolic extract of green tea showed a reduction in the number of Chromatid Type Aberration
i (CTA) in the experimental samples when compared to control samples. Hence, it may be
concluded that since green tea could cause cell death in HeLa cells and reduce the DNA
damage in cultured lymphocytes of cervical cancer patients it can be considered as a potent
anticancer agent against cervical carcinogenesis.