Antigenotoxic Potential of Punica granatum in Breast Cancer Patients

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dc.categoryBook Chapter
dc.contributor.authorSanthy, K S
dc.contributor.authorSrividya, M
dc.date.accessioned2017-01-24T19:51:30Z
dc.date.available2017-01-24T19:51:30Z
dc.date.issued2016
dc.departmentLife Science - Zoologyen_US
dc.description.abstractCancer is a disease that knows no geographic boundaries. Despite decades of basic and finical research and trials of promising new therapies, cancer remains a major cause of jrbidity and mortality. The post genomic era has now opened new avenues in cancer treatment, vhich is contemplated to be more effective and specific for tumor cells using various methods uailablefor the assessment ofDNA damage and repair in cancer patients such as the bacterial \mes test, the scoring of chromosome aberration (CA), micronuclei and sister chromatid Exchange (SCE) in proliferating cell populations although the frequency of cells with structural iromosomal aberrations in peripheral blood lymphocytes is the first biomarker for rotoxicity that shows an association with overall cancer risk. The present investigation icompasses Single Cell Gel Electrophoresis (SCGE)/Comet assay as an alternative for {togenetic test to assess the extent ofDNA damage in breast cancer patients undergoing ferent modalities of treatment viz., chemotherapy, chemotherapy + surgery, chemotherapy Ifadiotherapy and chemotherapy + surgery + radiotherapy. The present study also comprises • reduction in chromosomal damage by the addition of pomegranate extracts to peripheral ood lymphocyte culture as a biomarker tool for DNA repair capacity of test substance. ?refore, the DNA repair capacity of Pomegranate Fruit Extract (PEE) in cultures of human ripheral blood lymphocytes of breast cancer patients was examined.en_US
dc.identifier.urihttps://ir.avinuty.ac.in/handle/avu/1126
dc.langEnglishen_US
dc.publisher.nameDaya Publishing House' A Division of Astral International Pvt. Ltd. New Delhi - 110 002en_US
dc.publisher.typeNationalen_US
dc.titleAntigenotoxic Potential of Punica granatum in Breast Cancer Patientsen_US
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