Cardiac Biomarkers and Atherogenic Indices in Hypertensive Postmenopausal Women With Co-Morbidities

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dc.categoryJournal Article
dc.contributor.authorJeyanthi, G P
dc.date.accessioned2017-03-09T20:05:53Z
dc.date.available2017-03-09T20:05:53Z
dc.date.issued2014
dc.departmentBiochemistryen_US
dc.description.abstractPostmenopausal women are susceptible to various non-communicable diseases. Hypertension and hyperlipidemia contribute significantly to atherosclerotic cardiovascular disease. Hence, the present study was carried out to assess cardiac biomarkers and atherogenic indices in four groups of postmenopausal women namely norrnotensive postmenopausal women, hypertensive postmenopausal women, hypertensive postmenopausal women with diabetes and hypertensive postmenopausal women with renal insufficiency. Total cholesterol, HDL-cholesterol, triglyceride, VLDL-cholesterol and LDL-cholesterol were assessed in the subjects. Atherogenic index (LDl C/HDL-C), cardiac risk ratio (TC/HDL-C), atherogenic coefficient ((TC-HDL)/HDL) and atherogenic index ol plasma (log (TG/HDL C)) were calculated in the participants of the study. One way ANOVA and Kruskal Wallis test were performed. Statistical analysis was performed using SPSS16.0 statistical software. Total cholesterol was significantly increased in hypertensive postmenopausal women compared to the other groups namely hypertensive postmenopausal women with diabetes, hypertensive postmenopausal women with renal insulficiency and norrnotensive postmenopausal women. HDL-cholesterol was significantly decreased in hypertensive postmenopausal women witn renal insufficiency compared to the other three groups. Triglycerides and VLDL-choiesterol vyere significantly increased in hypertensive postmenopausal women compared to the control group. LDl.-cfiolesterol was significantly increased in experimental groups compared to norrnotensive control group. Atherogenic index, atherogenic coefficient, cardiac risk ratio and atherogenic index of plasma were significantly increased in experimental groups compared to norrnotensive postmenopausal women. Reduced levels of HDL cholesterol and elevated levels of other cardiac biomarkers and atherogenic indices reflected the onset/progression of atherosclerotic cardiovascular disease in hypertensive postmenopausal women with and without co-morbidities.en_US
dc.identifier.urihttps://ir.avinuty.ac.in/handle/avu/2075
dc.langEnglishen_US
dc.publisher.nameINTERNATIONAL JOURNAL OF PHARlMACEUTICAL RESEARCH AND BIO-SCIENCEen_US
dc.publisher.typeInternationalen_US
dc.titleCardiac Biomarkers and Atherogenic Indices in Hypertensive Postmenopausal Women With Co-Morbiditiesen_US
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