Cardiac Biomarkers and Atherogenic Indices in Hypertensive Postmenopausal Women With Co-Morbidities
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Date
2014
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Abstract
Postmenopausal women are susceptible to various non-communicable diseases. Hypertension and
hyperlipidemia contribute significantly to atherosclerotic cardiovascular disease. Hence, the present study was
carried out to assess cardiac biomarkers and atherogenic indices in four groups of postmenopausal women
namely norrnotensive postmenopausal women, hypertensive postmenopausal women, hypertensive
postmenopausal women with diabetes and hypertensive postmenopausal women with renal insufficiency. Total
cholesterol, HDL-cholesterol, triglyceride, VLDL-cholesterol and LDL-cholesterol were assessed in the subjects.
Atherogenic index (LDl C/HDL-C), cardiac risk ratio (TC/HDL-C), atherogenic coefficient ((TC-HDL)/HDL) and
atherogenic index ol plasma (log (TG/HDL C)) were calculated in the participants of the study. One way ANOVA
and Kruskal Wallis test were performed. Statistical analysis was performed using SPSS16.0 statistical software.
Total cholesterol was significantly increased in hypertensive postmenopausal women compared to the other
groups namely hypertensive postmenopausal women with diabetes, hypertensive postmenopausal women with
renal insulficiency and norrnotensive postmenopausal women. HDL-cholesterol was significantly decreased in
hypertensive postmenopausal women witn renal insufficiency compared to the other three groups. Triglycerides
and VLDL-choiesterol vyere significantly increased in hypertensive postmenopausal women compared to the
control group. LDl.-cfiolesterol was significantly increased in experimental groups compared to norrnotensive
control group. Atherogenic index, atherogenic coefficient, cardiac risk ratio and atherogenic index of plasma were
significantly increased in experimental groups compared to norrnotensive postmenopausal women. Reduced
levels of HDL cholesterol and elevated levels of other cardiac biomarkers and atherogenic indices reflected the
onset/progression of atherosclerotic cardiovascular disease in hypertensive postmenopausal women with and
without co-morbidities.