Protective Mechanisms of Moringa oleifera against CCl4-lnduced Oxidative Stress in Precision-Cut Liver Slices

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dc.categoryJournal Article
dc.contributor.authorPadma, P R
dc.date.accessioned2017-03-07T20:20:51Z
dc.date.available2017-03-07T20:20:51Z
dc.date.issued2010
dc.departmentBiochemistryen_US
dc.description.abstractObjective: The present study was designed to evaluate the efficacy of Moringa oleifera leaves against carbon tetrachloride (CCU-treated liver slices in vitro. Material and Methods: The study evaluated the antioxidant properties of Moringa oleifera leaves against GCh-induced oxidative damage in liver slices. Results: CCU treatment significantly decreased the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione S-transferase and caused decreased glutathione cbntent and increased the thiobarbituric acid-reacting substances (TBARS). Treatment with Morinqp oleifera extract increased the activities of antioxidant enzymes and glutathione content and reduced the levels of TBARS significantly. Observed reduction in the level of lipid! peroxides showed a decreased tendency of peroxidative damage. Discussion and Conclusion: We conclude that, under these experimental conditions, the leaf extracts effectively suppress CCU-induced oxidative stress. Our findings provide evidence to demonstrate that the possible mechanism of this activity may be due to the strong antioxidant property of the leaves.en_US
dc.identifier.urihttps://ir.avinuty.ac.in/handle/avu/1915
dc.langEnglishen_US
dc.publisher.nameForschende Komplementarmedizinen_US
dc.publisher.typeInternationalen_US
dc.titleProtective Mechanisms of Moringa oleifera against CCl4-lnduced Oxidative Stress in Precision-Cut Liver Slicesen_US
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