Protective Mechanisms of Moringa oleifera against CCl4-lnduced Oxidative Stress in Precision-Cut Liver Slices
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Date
2010
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Abstract
Objective: The present study was designed to evaluate
the efficacy of Moringa oleifera leaves against carbon
tetrachloride (CCU-treated liver slices in vitro. Material
and Methods: The study evaluated the antioxidant properties
of Moringa oleifera leaves against GCh-induced
oxidative damage in liver slices. Results: CCU treatment
significantly decreased the activities of antioxidant enzymes
such as superoxide dismutase, catalase, glutathione
peroxidase, glutathione reductase, and glutathione
S-transferase and caused decreased glutathione cbntent
and increased the thiobarbituric acid-reacting substances
(TBARS). Treatment with Morinqp oleifera extract
increased the activities of antioxidant enzymes and
glutathione content and reduced the levels of TBARS
significantly. Observed reduction in the level of lipid! peroxides
showed a decreased tendency of peroxidative
damage. Discussion and Conclusion: We conclude that,
under these experimental conditions, the leaf extracts effectively
suppress CCU-induced oxidative stress. Our
findings provide evidence to demonstrate that the possible
mechanism of this activity may be due to the strong
antioxidant property of the leaves.