A Study on Thrombolytic, Cytotoxic and Antioxidant Potential of Murraya Koenigii
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2012
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Abstract
The plant Murraya koer)igii was selected and analyzed for thrombolytic, cytotoxic and antioxidant potential. Phytochemical analysis
was performed in both aqueous and ethanolic extracts of Murraya koenigii to detect several kinds of phytoconstituents namely
carbohydrates, proteins, phenols, steroids, saponins, quinones, alkaloids, flavonoids, tannins and volatile oils. The thrombolytic
activity of the aqueous extract of the plant was found to be 26.17%. Correlation was carried out between serum cholesterol level
and thrombolytic activity of Murraya koenigii, where no correlation was obtained. The cytotoxicity of the plant was determined
using brine shrimp lethality assay which expressed a LC50 value of 6.45.Total antioxidant level in terms of Gallic acid equivalence
was found to be 350.81i0.99 mg/g. Thus the present findings suggest that, the plant has thrombolytic, cytotoxic and antioxidant
properties which could be explored for the treatment of cardiovascular diseases.