Assessment of an I Icancer Activity of Solanvm Torvljm L. Nanoparticles
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Date
2015
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Abstract
In recent years, metal nanoparticles
li.ive received considerable attention
III pharmaceutical applications. I’hese
n.I noparticles can be synthesized either
I hcmically or biologically. Biological
synthesis of nanoparticles is less time
I onsuming, less Mostly and more eco
Inendly. In the present study, the green
synlhesis of selenium nano particles from
the Solanum torvum fruit extract has been
tallied out and characterized by UV-Vis
sfx'clra, SEM and FTIR analysis. The
anliniicrobial activity of the synthesized
ScNI’s against various pathogens and also
the cytotoxic activity against MCF-7 breast
I .nicer cell line were determined. Solanum
u >1 1 um fruits (sundaikkai) were collected in
November and December 2013 from the
local areas of Coimbatore. The functional
groups were observed in the sample
tilling FTIR analysis. The SEM image was
analyzed to confirm the particle size and
.tpjiearance of club formed at 93nm. The
itniimicrobial activity was screened against
I-coll. Bacillus sp.. Pseudomonas sp. and
Kh'hsella sp. The maximum activity
occurs at 2mM concentration of selenium
naiioparticles. Exposure to increasing
Concentration of SeNPs showed dosedependent
cytotoxicity on MCF-7 cells.These results throw light on the potent
anticancer activity of Solanuin torvum
mediated selenium nanoparticles.