ANTIOXIDANT AND CYTOTOXIC EFFECTS OF METHANOL EXTRACTS 0¥ AMORPHOPHALLUS PAEONIIFOLIUS NI
| dc.category | Journal Article | |
| dc.contributor.author | Santhy, K S | |
| dc.date.accessioned | 2017-01-12T19:50:57Z | |
| dc.date.available | 2017-01-12T19:50:57Z | |
| dc.date.issued | 2015 | |
| dc.department | Life Science - Zoology | en_US |
| dc.description.abstract | Objectives; To identify the bioactive compounds present in Amorphophallus paeoniifolius and to evaluate the antioxidant and cytotoxic property of the plant extract. Methods; Preliminary phytochemical analysis was carried out to determine its major chemical constituents such as alkaloid.s, sterols, flavonoids, terpenoids, phenolic compounds, saponins, carbohydrates, glycosides, and tannins. Bioactive compounds were identified by gas chromatography - mass spectrometry (GC/MS) analysis. Antioxidant activity of the methanol extract were determined by two different methods viz., 2,2-diphenyl-2-picryl hydrazyl hydrate radical scavenging assay and reducing power assay. Furthermore, the extracts were tested for their ability to kill the proliferative cells (MCF-7) by (3-[4,5-dimethyl-thiazol-2-yl]-2,5-diphenyltetrazolium bromide) (MTT) assay. Results; Ten pharmacology important compounds were identified by GC/MS analysis. The higher antioxidant potential of the extracts was observed in both assays. The appreciable free radical scavenging activity of the extracts might be attributed to the secondary metabolites such as alkaloids, flavonoids, tannin.s, phenols, and sterols present in the extract. The results of MTT a,ssay indicated a significant growth inhibition at a low concentration of ICju values (51.07 pg/ml). Conclusion; The present study is an evidence to support the usage of the plant which possesses several antioxidant principles for medicinal uses. | en_US |
| dc.identifier.uri | https://ir.avinuty.ac.in/handle/avu/1039 | |
| dc.lang | English | en_US |
| dc.publisher.name | Asian Iournal of Pharmaceutical and Clinical Research | en_US |
| dc.publisher.type | International | en_US |
| dc.title | ANTIOXIDANT AND CYTOTOXIC EFFECTS OF METHANOL EXTRACTS 0¥ AMORPHOPHALLUS PAEONIIFOLIUS NI | en_US |
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