ULVA FASCIATA NANOPARTICLES CHARACTERIZATION AND ITS ANTICANCER ACTIVITY
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Date
2015
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Abstract
Seaweeds are non-flowering marine macro algae which are grown in
wide spectra. The edible green seaweed Diva fasicata shows potent
therapeutic value and it is used as nanoparticle agent in cancer therapy.
Synthesis of biological nanoparticles is physiologically toxic free with
more effective in the treatment of cancer. Hence Ulva fasicata was
developed as nanoparticles to treat against DAL cancer cell line in
albino mice. Ulva fasciata nanoparticles were developed in low cost
and most potential method and studied for its characterization like size,
morphology and active compounds using SEM, FTIR and AFM. After
confirmation of nanoparticles were exploring for its anticancer activity
against cancer cells. The characterization study showed that the
developed nanoparticles are spherical in shape with polydispersed and
few clusters were seen in the SEM micrograph. AFM image shows theparticles were in the
range of 50 to 190nm. FT-IR image depict majority of compounds were phenols and amines.
Those nanoparticles significantly increased the life span of cancer treated mice, decrease the
cancer cell count and reverse the liver fimctional enzymes level thus it’s proved an efficient
anticancer activity against cancer cells.. Thus it shows potent anticancer activity when
compare to its extract and the techniques used here was less expensive, low-energy way to
f:
make stable and all-natural nanoparticles.