Glycyrrhiza glabra - a Natural Panacea against Diarrhoea and Cancer

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dc.categoryConference Proceedings
dc.contributor.authorSylvia Subapriya, M
dc.contributor.authorRamya, M
dc.date.accessioned2017-02-20T19:10:45Z
dc.date.available2017-02-20T19:10:45Z
dc.date.issued2016
dc.departmentFood Science and Nutritionen_US
dc.description.abstractThe major food borne outbreaks of diarrhoeal diseases are caused by microbes such as Escherichia coli, Salmonella enterica and Shigella dysenteriae. The present study was conducted to develop nanoparticle coatings from the medicinal plant, Glycyrrhiza glabra against diarrhea and carcinoma. The GC/MS of nanoparticles reveals the following active phyto constituents namely 9-octadecenaL tetradecanoic acid, oleic Acid, z, z2, 5- Pentadecadien-1 -ol, cis-9,10-epoxyoctadecan-1 -ol and n-hexadecanoic acid. The antioxidant and thin layer chromatography of Glycyrrhiza glabra nanoparticles showed a maximum of 520 pg and phenolic compounds. The antimicrobial activity were tested by disc diffusion showed microbial inhibition of 11,15 and 14 mm against £.co// (MTCC 40), S.enterica (MTCC 3219) and S.dysenteriae (PSGIMS&R) respectively. Therefore, commercially available food packages such as PET bottles, zip lock covers and infant feeding bottles were coated with nanoparticles and tested for shelf-life for ten days. In nanocoated PET bottles and ziplock covers stored with tomato puree showed that till O'** day, there was no microbial growth. On the 10* day, 57,68 and 88 percentage of microbial inhibition was observed in PET bottles against E.coli (MTCC 40), S.enterica (MTCC 3219) and S.dysenteriae (PSGIMS&R) respectively. In nanocoated zip lock covers showed 38,63 and 83 percentage of microbial inhibition was observed against diarrhoeal pathogens. Nanocoated feeding bottles, showed a maximum microbial inhibition (84percentage) against diarrhoeal pathogens. Gel electrophoresis showed DNA damage to the Hela and Liver carcinoma cell lines and 50 and 48 percent apoptosis in the two cell lines respectively. Therefore, Glycyrrhiza glabra nanoparticles are effective in diarrrhoea prevention and cancer treatment.en_US
dc.identifier.urihttps://ir.avinuty.ac.in/handle/avu/1576
dc.langEnglishen_US
dc.publisher.nameNational Conference on Challenging Issues and Technological Approaches in Medicineen_US
dc.publisher.typeNationalen_US
dc.titleGlycyrrhiza glabra - a Natural Panacea against Diarrhoea and Canceren_US
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