In Silico and Pharmokinetic (Adme) Analysis for Selective Inhibitors of Tubulin as Potential Cure for Cancer
| dc.category | Journal Article | |
| dc.contributor.author | Annapurani, S | |
| dc.date.accessioned | 2017-03-07T21:39:04Z | |
| dc.date.available | 2017-03-07T21:39:04Z | |
| dc.date.issued | 2010 | |
| dc.department | Biochemistry | en_US |
| dc.description.abstract | Microtubules are extremely important in the process of mitosis, during which the duplicated chromosomes of a cell are separated into two identical sets before cleavage of the cell into two daughter cells. Their importance in mitosis and cell division makes microtubules an important target tor anticanccr drugs. y\ new class of simple synthetic antimitotic compounds based on 2-aroyliridolcs was drawn using MAESTRO and CHEMSKF/rCl!. flic crystal structure of TUBULIN was used as a target structure. It was obtained from RCSB Protein Data Bank with the PDB ID; IZ2B. High Throughput Virtual Screening, and Induced Fit Docking studies were carried out using GLIDE. Docking stuH>es was also carried out using GOLD. Interactions were noted for both ligand and synthetic compounds with the target protein. Energy values, GLIDE and GOLD scores were^PNIE studies were carried out '■ "To’rTnose compounds and its activity was predicted using PASS prediction. Based on this, 3-Benzyloxypheiiyl- (5-metlioxy-lpiiciiylsulfonyl- 1 U-2-indolyl)-inetliaiioi was found to be potent inhibitor for tubulin. We conclude, that 2-aroylindoies constitute an interesting new class of antitubulin agents with the potential to be clinically developed for cancer treatment. | en_US |
| dc.identifier.uri | https://ir.avinuty.ac.in/handle/avu/1925 | |
| dc.lang | English | en_US |
| dc.publisher.name | National Journal Of Sciencepersecond | en_US |
| dc.publisher.type | National | en_US |
| dc.title | In Silico and Pharmokinetic (Adme) Analysis for Selective Inhibitors of Tubulin as Potential Cure for Cancer | en_US |
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