ANTICANCER ACTIVITY OF METHANOLIC AND AQUEOUS EXTRACT OF ULVA FASCIATA IN ALBINO MICE
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Date
2012
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Abstract
Seaweeds are primitive non flowering aquatic plants, which have been a source of food, feed and medicine since ancient times. The selected green
seaweed U.fasciata collected from Gulf of Mannar Is a unique marine habitat that belongs to the diverse class of seaweeds. Hence the present study
was conducted with the specific objectives to explore the anticancer activity of green seaweed, Ulva fasciata. The anticancer activity was tested
against Dalton's ascitic lymphoma (DAL) in Swiss albino mice at the dose of 200 mg/kg. body weight In this study, drug treatment was given after
the 24 hrs of inoculation, once daily for 14 days. 5 -fluorouracil (20 mg/kg) was used as standard drug. The albino mice were evaluated for Median
Survival Time (MST), and cancer cell count, packed cell volume, hematological parameters was compared with the standard by collecting blood
from retro orbital blood vessel of mice. The parameters were reduced in tumor induced mice. These observations suggest that both the extract
MEUF and AEUF possess anticancer effect against Dalton's Ascitic Lymphoma (DAL)