Antioxidant and hepatoprotective effects of Clitoria ternatea leaf extracts by using in vivo model
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Date
2012
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Abstract
Herbal medicines are in great demand because of their great efficacy and little or no side effects. Many piant
extracts show promising antioxidant and free radicai scavenging activity. The plant used in the present study is Clitoria
ternatea (Sanskrit-Sankupushpam) belongs to the family Fabaceae . The in vivo studies were conducted using male
Wistar rats. Liver cells participate in a variety of metabolic activities and contain a host of enzymes. CCI4 is a known
hepatotoxin whose action is mediated by the cytochrome P450 (CYP), the extent of liver damage caused by ethanol-CCL
treatment was studied by estimating the serum marker enzymes and the circulating lipid profile. The effect of leaf extracts
was significantly higher in all the antioxidants suggests Clitoria ternatea a strong protection against oxidative
damage in CCI4 induced hepatotoxicity in rats. The observations made in vivo were also confirmed by histopathological
studies.