Solid Supports in the Synthesis of Few Vinyl Guinolones
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Date
2010
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Abstract
The present investigation involves use o f microwave technology aided by solid supports-ahimina,
montmorillonite clay, bentonite, silica gel , dowex and amberlite fo r the synthesis o f few 4-
substituted-3-vinyl quinolines and 4-substituted-3-vinyl quinoline-2(lH)-thiones, The results of
the microwave reactions aided by solid supports indicate significant increase in the yield o f
product and reduction in the time o f synthesis compared to classic conditions and in microwave
reactions without solid supports. Neutral alumina and KIO clay were found to be more efficient
in the synthesis o f chloro -4- alkyl -3-vinyl quinolines and 4- alkyl -3-vinyl quinoline-2(lH)-
thiones. The used solid-supports can be easily separated from the reaction mixture and recycled.