Alpha-amylase and alpha-glucosidase inhibitory property and antioxidant potential of Polyalthia longifolia bark extracts

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dc.categoryJournal Article
dc.contributor.authorJeyanthi, G P
dc.date.accessioned2017-03-08T23:18:25Z
dc.date.available2017-03-08T23:18:25Z
dc.date.issued2012
dc.departmentBiochemistryen_US
dc.description.abstractDiabetes mellitus is a metabolic disorder characterized by hyperglycemia and it is one of the free radical mediated ailments. Among the various anti-diabetic therapeutic approaches one major strategy is reducing gastrointestinal absorption of glucose by inhibition of carbohydrate metabolizing enzymes alpha-amylase and alpha-glucosidase In the present study the aqueous extracts of Polyalthia longifolia bark has been assessed for the inhibition of alpha-amylase and alpha-glucosidase and total antioxidant potential (FRAP assay). In vitro antioxidant activity of the ethanol extract (polar solvent) and hexane extract (non-polar solvent) has been assessed using various antioxidant model systems, viz DPPH, ABTS, NO, OH, SO and inhibition of in vitro lipid peroxidation. The aqueous extract of the bark exhibits highest alpha-amylase and alpha-glucosidase inhibition. Ethanol extract of Polyalthia longifolia is found to possess highest DPPH, ABTS, nitric oxide, hydroxyl, superoxide scavenging activity at lower concentration compared to the hexane extract. Also the ethanolic extract of Polyalthia longifolia is found to be good inhibitor of in vitro lipid peroxidation. Saturation in the enzyme inhibition and free radical scavenging activity has been attained in a concentration dependent manner. This study indicates significant alphaamylase and alpha-glucosidase inhibition, free radical scavenging potential and lipid peroxidation inhibition of Polyalthia longifolia bark which can be exploited for the treatment of various free radical mediated diseases like diabetes mellitus. Studies are being done on the various solvent extracts of the bark for enzyme inhibition to isolate the active compounds with potent inhibition for alpha-amylase, alpha-glucosidase and antioxidant potential.en_US
dc.identifier.urihttps://ir.avinuty.ac.in/handle/avu/2004
dc.langEnglishen_US
dc.publisher.nameInternational Journal of Chemical and Pharmaceutical Sciencesen_US
dc.publisher.typeInternationalen_US
dc.titleAlpha-amylase and alpha-glucosidase inhibitory property and antioxidant potential of Polyalthia longifolia bark extractsen_US
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