Browsing by Author "Lalitha, P"
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- ItemAcute Toxicity of the Ethanol Extract of Aerial Roots Of Rhaphidophora Aurea Twined over Lawsonia Inermis(2012) Lalitha, PThis study was performed to elucidate the possible toxic effect of the ethanolic extract of aerial roots of Rhaphidophora aurea twined over Lawsonia inermis on Swiss mice. Mice were orally administrated single dose o f 100,250,500, 750, 1000 and 2000 mg/kg of ethanol extract and the mortality was observed for 14 days post treatment of extract. These results state that ethanol extract of Rhaphidophora aurea twined over Lawsonia inermis is toxicologically safe by oral administration.
- ItemAcute Toxicity Study of Extracts of Eichhornia Crassipes (Mart) Solms(2012) Lalitha, PEichhornia crassipes is a water weed and is considered as a threat to the environment and economy. The purpose of the study was to test the acute oral toxicity of the extracts of the plant. Acute toxicity of ethyl acetate, aqueous extracts and methanol fractionate of Eichhornia crassipes was evaluated in Swiss mice. The acute toxicity studies were carried out based on OECD guidelines 423 and fixed dosage studies was adopted where the limit dose is 2000mg/kg body weight of test animal. The animals were orally administered a single dose of 100, 250, 500,750, 1000, 2000mg/kg body weight. Signs of toxicity and mortality were noted after 1, 4 and 24h of administration of the extract for 14 days. The highest dose administered (2000mg/kg body weight) did not produce mortality or changes in general behaviour of the test animals. These results indicate the safety of the oral administration of ethyl acetate extract, aqueous extract and methanol fractionate of aqueous extract of Eichhornia crassipes.
- ItemAdsorption of Chromium (VI) From Aqueous Solution Using Activated Carbon From the Pods of Wood Apple(2010) Lalitha, P; Renugadevi, NIn this study activated carbon from pods of wood apple, an agro waste has been used as an adsorbent for removal of Cr (VI) from aqueous solutions. Parameters, such as adsprbent dosage, concentration of the adsorbate, contact time, and pH were optimized with regard to Cr (VI) removal using the selected adsorbent. To analyze the efficiency of the activated carbon from wood apple (ACW) the experiments were also conducted with commercial activated carbon (ACC) and the result compared. The adsorption of Cr (VI) was found to be concentration and pH dependent. Percentage removal of Cr (VI) increased with decrease in pH and increase in adsorbent dosage for both ACC and ACW. On applying the adsorption data to Langmuir equation, linear plots of 1/Ce vs x/m obtained shows that the adsorption of Cr (VI) using activated carbon prepared from the pod of wood apple and commercially activated carbon followed Langmuir adsorption isotherm. Thus adsorption technique using activated carbon from agro wastes, like pods of wood apple is found to be an efficient method for the removal of heavy metals, like Cr (VI) from aqueous solutions.
- ItemAdsorption of Maiachite Green Using a Low-Cost Activated Carbon Prepared From Cassia Fstuaf(2011) Lalitha, P; Renugadevi, Nin the present study the efficiency of the carbon adsorbent prepared from the Cassia fistula seeds was tested for the removal of malachite green dye from aqueous solution. The parameters, such as pH, adsorbent dosage and initial dye concentration were systematically evaluated. It is an N- methylated diaminotriphenyl methane dye widely used for colouring purpose and highly cytotoxic to mammalian cells. The percentage removal of malachite green increased with concentration of the dye solution. Nearly 40% adsorption was noted at pH 10 in 180 min of contact time at initial concentration of 4 0 0 mg/L with 3 0 0 mg of the low-cost adsorbent. Removal of malachite green increased from 2 4 .0 5 to 2 8 .2 3% with increasing adsorbent dosage from 3 0 0 to 600 mg in 180 min of agitation time, using 100 mL of dye solution of initial concentration of 4 0 0 mg/L. Langmiur adsorption isotherm plots and Freundlich adsorption isotherm plots were linear showing the applicability of the isotherms for malachite green adsorption.
- ItemAllantoin from the leaves of Pisonia grandis R.Br.(2011) Subhashini K. Sripathi; Lalitha, PPhytochemical investigation o f the leaves o f the Pisonia grandis afforded three compounds (I-3). Compound I was identified as the insulin mimetic molecule pinitol and its isolation was reported in our earlier paper'. The present paper deals with the isolation o f compounds 2 and 3. whose structures were established as that o f allantoin and its hydrogen bonded isomeric crystalline form, based on spectroscopic data and it is the first report o f isolation of allantoin and its hydrogen bonded isomer from Pisonia genus and from this species.
- ItemAllantoin from the leaves of Pisonia grandis R.Br.(2011) Lalitha, PPhytochemical investigation of the leaves of the Pisonia grandis afforded three compounds (1-3). Compound 1 was identified as the insulin mimetic molecule pinitol and its isolation was reported in our earlier paper1. The present paper deals with the isolation of compounds 2 and 3, whose structures were established as that of allantoin and its hydrogen bonded isomeric crystalline form, based on spectroscopic data and it is the first report of isolation of allantoin and its hydrogen bonded isomer from Pisonia genus and from this species.
- ItemAn Alternative Cost Effective Method for Adsorption of Phenols in Effluents from Oils Refineries(1998-04) Lalitha, P; Sivakamasundari, S
- ItemAnalysis of Curcumin Content of Turmeric Samples from Various States of India(2016) Lalitha, PTurmeric samples were collected from various states of India and analysed for its curcumin content. The results o f the study disclose turmeric samples from Odisha and Andra Pradesh to have comparatively higher percentage of curcumin than the other samples. The quality of curcumin and hence the activity of turmeric depends on the quantity of curcumin in it. The findings reveal the curcumin content to depend on geographical variation which influences the soil, environment, climatic conditions etc.
- ItemAnalysis of the Optical Properties of Silver Nanoparticles Synthesized Using Amaranthus Extracts(2015) Lalitha, POptical properties of metal nanomaterials hold both fundamental and practical significance. Nanosilver exhibits fascinating optical properties directly related to the Surface Plasmon Resonance(SPR) which corresponds to the shape and size distribution of the particles. UVVisible spectral measurements are useful in predicting the size of nanosilver. Optical response of nanoparticles makes them potentially useful for nanoscopic sensors, biological labels and electronics. The present study deals with the biogenic synthesis of silver nanoparticles using Amaranthus leaf extract and studying its optical properties in a UV-Visible spectrophotometer. The results of the study clearly shows that the concentration of the capping molecule to be responsible for the shape and particle size distribution of silver nanoparticles.
- ItemAnti-Inflammatory Activity Of The Various Solvent Extracts Of Eichhornia crassipes (Mart.) Solms(2013) Lalitha, PThe various solvent extracts of Eichhornia crassipes (Mart.) Solms was studied for its antiinflammatory activity on formaldehyde induced paw oedema in Male Swiss Albino mice. Due the presence of wide range of phytochemical constituents in the petroleum ether, ethyl acetate and aqueous extracts of Eichhornia crassipes as noted from the results of the phytochemical screening, these extracts were assayed for the in vivo anti-inflammatory activity. It was found that all the tested extracts of leaves and shoot portion of Eichhornia crassipes possess significant anti-inflammatory activity. Percent inhibition obtained from antiinflammatory activity has shown that the extracts have very strong activity to prevent pains which provides strong scientific evidence to the folkloric use of this plant in the treatment of inflammation in animals.
- ItemAnti-inflammatory and antioxidant activity index of the aerial roots of Rhaphidophora aurea (Linden Ex Andre) intertwined over different host trees(2014) Lalitha, PRhaphidophora aurea is a common ornamental plant with aerial roots required for its support. It climbs over host trees and sucks the nutrients of the host. A similar species Epiprenum pinnatum is reported to possess anticancer activity. The leaves of Rhaphidophora aurea are toxic but there are no reports on the uses of aerial roots. The weird property of the aerial roots to twine over the host and suck its nutrients persuaded us to explore the properties of the host and uncover the acquired therapeutic properties of the aerial roots of Rhaphidophora aurea. Materials and methods: The antioxidant activity index of various solvent extracts of the aerial roots of Rhaphidophora aurea intertwined over four different host trees were evaluated by DPPH radical scavenging method and reducing power assay. IC50, EC50 and antioxidant activity index (AAI) were taken up for antioxidant assessment. The ethyl alcohol extract of the aerial roots of Rhaphidophora aurea twined over Lawsonia inermis (MM) and Areca catechu (MB) were tested for anti-inflammatory activity in formalin induced Swiss Albino mice paw oedema model and the paw thickness was measured each one hour upto six hours. Results and Conclusions: Among all the extracts evaluated, the ethyl alcohol extract of the aerial roots of Rhaphidophora aurea twined over four host trees specially Azadirachta indica (MN) exhibit higher antioxidant activity with a strong AAI (5.29) as compared to AAI (2.74) of standard Ascorbic acid. In formalin induced inflammation model, the dose (100mg/kg) produced significant percentage inhibition of mice paw oedema compared to control group. It can be concluded that alcoholic extract of aerial roots of Rhaphidophora aurea intertwined over four different host trees shows good in vitro antioxidant and in vivo anti-inflammatory activity and hence of good promise in pharmaceutical field.
- ItemAntiaging Activity of the Skin Cream Containing Ethyl Acetate Extract of Eichhornia Crassipes (Mart.) Solms(2014) Lalitha, PEichhornia crussipes (Mart.) Solms possess many antioxidants like glutathione, ascorbic acid etc. Two skin creams of the ethyl aectate extract E.crassipcs were evaluated for its antiageing effieaey by DNA damage inhibition assay and DF’PI I radical scavenging assay. I'he DNA damage inhibition and DPPII radical scavenging ability offered by the skin creams increased with increase in concentration ( I mg to 20 mg) for both the creams. The results suggest the promising use of the plant in cosmeeeutical industry as formulations.
- ItemAntiepileptic and Molecular Docking - Based Approaches(2022-05) Pooja, K; Lalitha, P
- ItemAntifungal Activity of Few Nitrogen Heterocycles Synthesized Under Microwave Irradiation(2010) Lalitha, PQuinoline compounds possess a wide range of antibacterial, antifungal and antimutagenic properties. The present work involves synthesis of three heterocycles-4- Phenyl 3-vinyl quinolin-2-one (1). 4-phenyl-3-chloroquinoline (2), 4-phenyl-3-vinyl quinoline-2-thione (3) utilizing microwave technology and testing their antifungal activity against 4 fungi namely Aspergillus flavus, Rhizopus nigricans, Mucor hiemalis and Candida albicans. Antifungal studies of compounds showed good fungal activify. The antimicrobial significance of the synthesized compounds is well evident from the study.
- ItemAntimicrobial Activity and Phytochemical Screening on an Ornamental Foliage Plant, Pothos aurea (Linden ex Andre)(2010) Lalitha, PThe in vitro antimicrobial activity of the petroleum ether, acetone and ethanolic extracts of the aerial roots of Pothos aurea (commonly known as money plant) that climbed on Areca catechu (betel nut palm) and Lawsonia inlermis (Mehandhi plant) were investigated. The extracts exhibited antimicrobial activities with the zones of inhibition ranging from 0 to 15, 10 to 15 and 10 to 15 mm for petroleum ether, acetone and ethanol respectively. The extracts of the aerial roots from Areca catechu showed good antimicrobial activity. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, glycosides and anthraquinone in the extracts of aerial roots intertwined over Areca catechu and in the extracts of aerial roots of Pothos aurea collected from Lawsonia inlermis. The potential of the crude stem extracts of Pothos aurea to inhibit the growth of bacteria and fiingi is a sign of its broad spectrum antimicrobial potential which may be used in the management of microbial infections.
- ItemAntimicrobial Activity of Perspiration Pads and Cotton Cloth Fabricated with the Ethyl Acetate Extract of Eichhornia crassipes (Mart.) Solms(2014) Lalitha, PWaterhyacinth is one of the most dangerous aquatic weeds causing various ecological and environmental issues. The plant has several pharmaceutical properties in spite of its harmful nature. In the present study, perspiration pads and cotton cloth fabricated with the ethyl acetate extract o f waterhyacinth were evaluated for its activity against Corynebacterium. Perspiration pads and samples of cotton cloth were fabricated with ethyl acetate extract of Eichhornia crassipes by three methods, namely, dipping, sonication, and homogenization. Ihe antimicrobial activity of the fabricated textile materials was tested against Corynebacterium, a microorganism commonly seen in human .sweat. Disc diffusion method (AATCC 147) was used for evaluating the antimicrobial nature of the fabricated samples. Sonication was found to be efficient for coating of the extract on the cotton cloth, whereas dipping method was found to be efficient in case of perspiration pads. No bacterial growth was observed under and on the fabricated cloth and perspiration pads indicating that the fabrics possess bacteriostatic property and not bactericidal property and the absence of leaching of the extract. The results showed significant antimicrobial activity of the ethyl acetate extract of Eichhornia crassipes coated onto fabrics against Corynebacterium with no growth under and on the test sample.
- ItemAntimicrobial Activity of Solvent Extracts of Eichhornia Crassipes (Mart.) Solms(2013) Lalitha, PEichhornia crassipes (Mart.) Solms, Waterhyacinth , once looked upon nonchalantly, has received supreme interest in recent years owing to its constructiveness in various fields. The solvent extracts of waterhaycinth was tested against a bacteria Staphylococcus albus by disc diffusion method and a fungal stains Mucor sp by streak plate method. Acetone extract evidenced better activity against the microbes among other extracts. The result adds to the value of the plant in pharmaceutical field as an antimicrobial agent.
- ItemAntimicrobial Testing of the Extracts of Samanea saman (Jacq.)Merr(2010) Lalitha, PThe plant extracts o f Samanea saman (Jacq.)Merr and its fractionated portions were examined for their antibacterial and antifungal activity. Two bacteria- Escherichia Coli, staphylococcus aureus and two fungi Aspergillus flavus, Candida albicans were used fo r the studies. The extracts were found to exhibit appreciable antimicrobial activity.
- ItemAntioxidant Activities of the Extracts of the Aerial Roots of Pothos Aiirea (Linden ex Andre)(2010) Lalitha, PThe petroleum ether, ethyl acetate and chloroform extracts o f the aerial roots o f Pothos aurea intertwined over on Lawsonia inermis (MM) and Areca catechu (MP) were examined fo r their phytochemical constituents and for their in vitro activities using I, l-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay and reducing power assay. Higher antioxidant potential o f the extracts was observed in both DPPH scavenging assay and reducing capacity assay.