Gayathri Devi, S2017-03-092017-03-092014https://ir.avinuty.ac.in/handle/avu/2082Objective: The present study was attempted to compare the in vitro free radical scavenging activity in the leaves, fruits and roots of Cleome viscose and Trichodesmaindicum. Methods: The leaves, fruits and roots of Cleome viscose and Trichodesmaindicum were extracted with solvents namely petroleum ether, benzene, chloroform, ethyl acetate and ethanol for the determination of free radical scavenging activity. The antioxidant activity was evaluated by determining ABTS, DPPH, superoxide, nitric oxide, hydroxyl radicals, hydrogen peroxide scavenging and inhibition of in vitro lipid peroxidation. Results: The chloroform and ethyl acetate extract of the roots of Trichodesmaindicum and the ethyl acetate extract of the fruit of Cleome viscose exhibits strong inhibition against DPPH radicals. The ethyl acetate and ethanol extract of the leaves, fruits and roots of Cleome viscose and ethanol extract of the leaves, fruits and roots of Trichodesmaindicum showed signi icant ABTS radical scavenging activity. Petroleum ether extract of the leaves of Cleome viscose and Trichodesmaindicum was found to possess potent superoxide scavenging activity. The maximum nitric oxide scavenging activity was found to be exhibited by the benzene extract of the fruit of Trichodesmaindicum. Ethyl acetate and benzene extract of the leaf of Trichodesmaindicum reveals the signi icant activity of hydroxyl radical scavenging activity. Conclusion: Based on the results, it can be concluded that the extracts of both the medicinal plants Cleome viscose and Trichodesrr,aindicum have great potential of free radical scavenging activity.